PURE PN / PDRN

Bio-reparative DNA-based technology for skin regeneration and recovery

Polynucleotide technology represents an advanced bio-reparative approach in modern skincare, designed to support visible skin regeneration, recovery, and structural quality at the cellular level.
In cosmetic formulations, polynucleotides are used to improve the appearance of skin affected by aging, stress, inflammation, and environmental damage, promoting a healthier, more resilient, and revitalized complexion.

In cosmetic science, polynucleotides are commonly classified into two types — PDRN and PN — which belong to the same biological family but differ in molecular weight and functional behavior in the skin.

Formulation Philosophy

Polynucleotides are formulated as part of multi-component bio-reparative cosmetic systems, rather than as standalone actives.
They are typically supported by peptides, amino acids, hyaluronic acid systems, vitamins, minerals, and barrier-supporting components to ensure balanced regeneration, hydration, and protection.

Both forms of polynucleotides are obtained from purified salmon milt DNA, using advanced extraction and purification technologies to ensure high biocompatibility, safety, and skin tolerance.
The formulation strategy focuses on supporting natural skin recovery mechanisms without aggressive stimulation or irritation.

Scientific Rationale

Skin aging and damage are closely associated with inflammation, oxidative stress, dehydration, and reduced regenerative capacity.
At the cellular level, impaired DNA signaling and disrupted repair processes lead to decreased collagen synthesis, loss of elasticity, and weakened skin structure.

Polynucleotides function as biological support molecules, helping skin cells optimize regeneration, improve metabolic balance, and maintain structural integrity.
Their cosmetic value lies in their ability to work in harmony with the skin’s natural renewal systems while maintaining excellent tolerability.

Two Types of Polynucleotides

PDRN (Polydeoxyribonucleotide)

Lower– to medium–molecular-weight polynucleotides

PDRN consists of shorter DNA fragments with a lower molecular weight.
This structure allows PDRN to interact more dynamically with cellular signaling pathways involved in regeneration and repair.

In cosmetic use, PDRN supports:

• activation of skin renewal processes
• stimulation of collagen and elastin synthesis
• improvement of skin density, elasticity, and tone
• visible reduction of signs of fatigue and aging

PDRN is particularly suited for improving overall skin quality and supporting active regeneration phases.

PN (Polynucleotide)

High-molecular-weight polynucleotides

PN represents a higher molecular weight form of polynucleotides, composed of longer DNA chains.
Its larger molecular structure enables more prolonged presence and sustained bio-supportive activity within the skin.

In cosmetic formulations, PN contributes to:

• long-lasting regenerative and recovery support
• reinforcement of skin structure and firmness
• support of hydration balance and tissue integrity
• calming of stressed, sensitive, or compromised skin

PN is often associated with extended recovery and stabilization rather than rapid cellular signaling.

Mechanism of Cosmetic Action

Polynucleotides support skin regeneration through complementary biological pathways, including:

• modulation of inflammatory balance
• support of growth-factor-related signaling
• stimulation of microcirculation and tissue repair
• contribution to DNA recovery and cellular renewal mechanisms

The difference in molecular weight between PDRN and PN determines the depth, duration, and functional focus of their activity within the skin.

Functional Role in Skin Care

Within cosmetic skincare formulations, polynucleotide technology is used to:

• support visible skin regeneration and recovery
• improve firmness, elasticity, and skin density
• enhance hydration and skin smoothness
• reduce visible signs of aging and fatigue
• support post-stress and post-procedure skin recovery

Both forms are suitable for repeated use and long-term cosmetic care.

Responsible Cosmetic Use Note

Polynucleotide technology (PDRN and PN) is a  bio-reparative system intended to improve the appearance, quality, and resilience of the skin.